LINKS TO HLRCC RESEARCH - RCC (Renal Cell Carcinoma)
2014Potential genetic anticipation in hereditary leiomyomatosis-renal cell cancer (HLRCC)
This article describes that the average age of onset of kidney cancer decreases with each generation.
2013Kidney cancer - UK incidence statistics
Also has world-wide information.Evaluation and screening for hereditary renal cell cancers
Confirms the recommendations of the HLRCC Handbook.
2011NCCN Task Force Report: Optimizing Treatment of Advanced Renal Cell Carcinoma, With Molecular Targeted Therapy
This provides a comprehensive overview of drug treatments and rationales for RCC.Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion
This article describes the effect of reduced fumarase activity on RCC metastasis and wound healing.High-Dose Interleukin-2 Therapy for Metastatic Renal Cell Carcinoma and Metastatic Melanoma: Still the Standard
Interleukin 2 (IL-2, Proleukin) can produce a complete cure for metastatic renal cell cancer was described in 2002.Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma
The link is to the abstract with the full text available on subscription. A new study showing that type 2 papillary renal cell carcinoma may be the only symptom of HLRCC in some individuals. This study also identified and characterized 21 novel FH mutations.Familial and inherited renal cancers
The link is to the abstract with the full text available on subscription. This describes RCC in BHD, VHL and HLRCC, is well illustrated and highlights the need for RCC in HLRCC to be treated with radical surgery.Renal cell cancer among African Americans: an epidemiologic review
This open access article has a comprehensive analysis of statistics of possible causes of RCC with 127 references.CASE REPORTS : Spontaneous Regression of Metastatic Type II Papillary Renal Cell Carcinoma
Paper on spontaneous regression of mRCC.Thermal ablation of small renal masses: intermediate outcomes from a Canadian center
These 2 links are to the abstracts, subscription required for full articles. They describe good results from cryoablation (CA) and radio frequency ablation (RFA). These are nephron sparing procedures that destroy renal tissue in situ rather than by surgical removal. However these techniques are not recommended for HLRCCtumors - consult HLRCC Handbook.
2010The renal cell carcinoma market: Votrient to challenge Sutent’s lead
Discussion of different drugs for treating RCC.Feasibility and effects of high-dose hypofractionated radiation therapy and simultaneous multi-kinase inhibition with sunitinib in progressive metastatic renal cell cancer
This paper describes a break-through in the treatment of metastatic RCC by sensitizing the cancer cells with sunitinib in parallel with radiation therapy.Therapies for advanced kidney cancer
Written for the Kidney Cancer Association and has description of different drugs for treating advanced RCC.
2009Genetic Basis of Bilateral Renal Cancer: Implications for Evaluation and Management
General discussion of bilateral tumors for a number of genetic conditions including HLRCC.Genetic Basis for Kidney Cancer: Opportunity for Disease-Specific Approaches to Therapy
Targeted treatments for kidney cancers.Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient
The link is to the article abstract. The full article PDF is available on subscription. Although RCC is usually found in adults this article describes an 11-year old boy who was diagnosed with RCC on his first HLRCC screening. Useful discussion on screening guidelines.
2007HIF and fumarate hydratase in renal cancer
ull detailed technical article covering the suggested causes of RCC in VHL as well as HLRCC.The Morphologic Spectrum of Kidney Tumors in Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) Syndrome
The link is to the article abstract. The full article PDF is available on subscription. Technical discussion of tumor types associated with HLRCC.Renal Follow-up of HLRCC Syndrome Patients
This has a recommendation for 6-monthly RCC follow-up screening with MRI contrast.
2005Hereditary form of RCC best treated aggressively, study shows
The author recommends surgical therapy early in the course of treatment of HLRCC patients instead of wait-and-see management.